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The gamma-aminobutyric acid type B (GABAB) receptor agonist baclofen inhibits morphine sensitization by decreasing the dopamine level in rat nucleus accumbens

机译：γ-氨基丁酸B型（GABAB）受体激动剂巴氯芬通过降低伏隔核中的多巴胺水平来抑制吗啡敏化

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摘要

BackgroundRepeated morphine exposure can induce behavioral sensitization. There are evidences have shown that central gamma-aminobutyric acid (GABA) system is involved in morphine dependence. However, the effect of a GABAB receptor agonist baclofen on morphine-induced behavioral sensitization in rats is unclear.

机译：背景反复的吗啡暴露可引起行为敏感性。有证据表明，中央γ-氨基丁酸（GABA）系统参与吗啡依赖性。但是，尚不清楚GABA B受体激动剂巴氯芬对吗啡诱导的大鼠行为敏化的影响。

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期刊名称 Behavioral and Brain Functions : BBF
作者
Zhenyu Fu; Hongfa Yang; Yuqiang Xiao; Gang Zhao; Haiyan Huang;
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作者单位

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年(卷),期 2012(8),-1
年度 2012
页码 20
总页数 10
原文格式 PDF
正文语种
中图分类神经科学;医学行为学;
关键词
GABA receptor Morphine Sensitization Dopamine Nucleus accumbens Baclofen;

机译：GABA受体;吗啡;致敏作用;多巴胺;伏隔核;巴氯芬;

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专利

1. The gamma-aminobutyric acid type B (GABAB) receptor agonist baclofen inhibits morphine sensitization by decreasing the dopamine level in rat nucleus accumbens [J] . Zhenyu Fu, Hongfa Yang, Yuqiang Xiao, Behavioral and Brain Functions . 2012,第1期

机译：γ-氨基丁酸B型（GABAB）受体激动剂巴氯芬通过降低伏隔核中的多巴胺水平来抑制吗啡敏化
2. Cholecystokinin inhibits evoked inhibitory postsynaptic currents in the rat nucleus accumbens indirectly through gamma-aminobutyric acid and gamma-aminobutyric acid type B receptors. [J] . Kombian SB, Ananthalakshmi KV, Parvathy SS, Journal of Neuroscience Research . 2005,第3期

机译：胆囊收缩素通过γ-氨基丁酸和γ-氨基丁酸B型受体间接抑制大鼠伏隔核中诱发的抑制性突触后电流。
3. Effects of co-administration of the GABAB receptor agonist baclofen and a positive allosteric modulator of the GABAB receptor, CGP7930, on the development and expression of amphetamineinduced locomotor sensitization in rats [J] . CedilloL.N., MirandaF. Pharmacological reports: PR . 2013,第5期

机译：GABAB受体激动剂巴氯芬和GABAB受体正变构调节剂CGP7930共同给药对苯丙胺诱导的运动敏化的发展和表达的影响
4. A Subpopulation of Mesencephalic Dopamine Neurons Interfaces the Shell of Nucleus Accumbens and the Dorsolateral Striatum in Rats [C] . Yvette C. van Dongen, Bogdan P. Kolomiets, Henk J. Groenewegen, Triennial Meeting of the International Basal Ganglia Society . 2009

机译：中脑多巴胺神经元的亚群界面嵌入大鼠的核心腺壳和背侧纹状体
5. Modulation of gamma-aminobutyric acid (GABA) type A receptor-mediated responses in spinal dorsal horn neurons by mu-opioid receptor agonists and calcium(2+)/calmodulin-dependent protein kinase and Monte Carlo simulation of the GABAergic synaptic transmission. [D] . Wang, Rong. 1995

机译：γ-氨基丁酸（GABA）A型受体介导的mu阿片类受体激动剂和钙（2 +）/钙调蛋白依赖性蛋白激酶和Monte Carlo模拟的GABA能突触传递的脊髓背角神经元。
6. Chronic administration of morphine is associated with a decrease in surface AMPA GluR1 receptor subunit in dopamine D1 receptor expressing neurons in the shell and non-D1 receptor expressing neurons in the core of the rat nucleus accumbens [O] . Michael J. Glass, Diane A. Lane, Eric E.O. Colago, -1

机译：长期服用吗啡与大鼠伏伏核中多巴胺D1受体表达神经元和非D1受体表达神经元的表面AMPA GluR1受体亚基减少有关
7. The gamma-aminobutyric acid type B (GABA) receptor agonist baclofen inhibits morphine sensitization by decreasing the dopamine level in rat nucleus accumbens [O] . 2012

机译：γ-氨基丁酸B型（GABA）受体激动剂巴氯芬通过降低伏隔核中的多巴胺水平来抑制吗啡致敏

The gamma-aminobutyric acid type B (GABAB) receptor agonist baclofen inhibits morphine sensitization by decreasing the dopamine level in rat nucleus accumbens

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