Two new 2-alkylquinolones inhibitory to the fish skin ulcer pathogen Tenacibaculum maritimum produced by a rhizobacterium of the genus Burkholderia sp.

摘要

Exploration of rhizobacteria of the genus Burkholderia as an under-tapped resource of bioactive molecules resulted in the isolation of two new antimicrobial 2-alkyl-4-quinolones. (E)-2-(Hept-2-en-1-yl)quinolin-4(1H)-one (>1) and (E)-2-(non-2-en-1-yl)quinolin-4(1H)-one (>3) were isolated from the culture broth of strain MBAF1239 together with four known alkylquinolones (>2 and >4–>6), pyrrolnitrin (>7), and BN-227 (>8). The structures of >1 and >3 were unambiguously characterized using NMR spectroscopy and mass spectrometry. Compounds >1–>8 inhibited the growth of the marine bacterium Tenacibaculum maritimum, an etiological agent of skin ulcers in marine fish, offering new opportunities to develop antibacterial drugs for fish farming.