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Use of bio-mimetic three-dimensional technology in therapeutics for heart disease

机译:仿生三维技术在心脏病治疗中的应用

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摘要

Due to the limited self-renewal capacity of cardiomyocytes, the mammalian heart exhibits impaired regeneration and insufficient ability to restore heart function after injury. Cardiovascular tissue engineering is currently considered as a promising alternative therapy to restore the structure and function of the failing heart. Recent evidence suggests that the epicardium may play critical roles in regulation of myocardial development and regeneration. One of the mechanisms that has been proposed for the restorative effect of the epicardium is the specific physiomechanical cues that this layer provides to the cardiac cells. In this article we explore whether a new generation of epicardium-mimicking, acellular matrices can be utilized to enhance cardiac healing after injury. The matrix consists of a dense collagen scaffold with optimized biomechanical properties approaching those of embryonic epicardium. Grafting the epicardial patch onto the ischemic myocardium—promptly after the incidence of infarct—resulted in preserved contractility, attenuated ventricular remodeling, diminished fibrosis, and vascularization within the injured tissue in the adult murine heart.
机译:由于心肌细胞的自我更新能力有限,因此哺乳动物心脏的再生受到损害,受伤后恢复心脏功能的能力不足。心血管组织工程学目前被认为是恢复衰竭心脏结构和功能的有前途的替代疗法。最近的证据表明,心外膜可能在调节心肌发育和再生中起关键作用。已经提出的用于恢复心外膜的作用的机制之一是该层提供给心肌细胞的特定物理力学线索。在本文中,我们探讨了是否可以使用新一代的模仿心外膜的无细胞基质来增强损伤后的心脏愈合。基质由致密的胶原蛋白支架组成,具有与胚胎心外膜接近的最佳生物力学性能。在心梗发生后立即将心外膜片移植到缺血性心肌上,可保持收缩力,减弱的心室重塑,减少纤维化以及成年鼠心脏受损组织内的血管形成。

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