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Mechanisms to Avoid and Correct Erroneous Kinetochore-Microtubule Attachments

机译:避免和纠正错误的动臂微管附件的机制

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摘要

In dividing vertebrate cells multiple microtubules must connect to mitotic kinetochores in a highly stereotypical manner, with each sister kinetochore forming microtubule attachments to only one spindle pole. The exact sequence of events by which this goal is achieved varies considerably from cell to cell because of the variable locations of kinetochores and spindle poles, and randomness of initial microtubule attachments. These chance encounters with the kinetochores nonetheless ultimately lead to the desired outcome with high fidelity and in a limited time frame, providing one of the most startling examples of biological self-organization. This chapter discusses mechanisms that contribute to accurate chromosome segregation by helping dividing cells to avoid and resolve improper microtubule attachments.
机译:在分裂脊椎动物细胞时,必须以高度定型的方式将多个微管连接到有丝分裂的动植物上,每个动粒动姐妹仅在一个纺锤极上形成微管附件。由于运动因子和纺锤体极的位置不同以及初始微管附着的随机性,实现该目标的确切事件顺序在各个细胞之间差异很大。尽管如此,这些与动植物的偶然相遇最终还是在有限的时间内以高保真度实现了理想的结果,这是生物学自组织最令人震惊的例子之一。本章讨论通过帮助分裂细胞避免和解决不正确的微管附着而有助于精确染色体分离的机制。

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