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Complex conjugate resolved heterodyne swept source optical coherence tomography using coherence revival

机译:使用相干复兴的复杂共轭分辨外差扫频源光学相干层析成像

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摘要

We describe a simple and low-cost technique for resolving the complex conjugate ambiguity in Fourier domain optical coherence tomography (OCT) that is applicable to many swept source OCT (SSOCT) systems. First, we review the principles of coherence revival, wherein an interferometer illuminated by an external cavity tunable laser (ECTL) exhibits interference fringes when the two arms of the interferometer are mismatched by an integer multiple of the laser cavity length. Second, we report observations that the spectral interferogram obtained from SSOCT systems employing certain ECTLs are automatically phase modulated when the arm lengths are mismatched this way. This phase modulation results in a frequency-shifted interferogram, effectively creating an extended-depth heterodyne SSOCT system without the use of acousto-optic or electro-optic modulators. We suggest that this phase modulation may be caused by the ECTL cavity optical pathlength varying slightly over the laser sweep, and support this hypothesis with numerical simulations. We also report on the successful implementation of this technique with two commercial swept source lasers operating at 840nm and 1040nm, with sweep rates of 8kHz and 100kHz respectively. The extended imaging depth afforded by this technique was demonstrated by measuring the sensitivity fall-off profiles of each laser with matched and mismatched interferometer arms. The feasibility of this technique for clinical systems is demonstrated by imaging the ocular anterior segments of healthy human volunteers.
机译:我们描述了一种简单且低成本的技术,用于解决傅立叶域光学相干断层扫描(OCT)中的复杂共轭模糊性,该技术适用于许多扫频源OCT(SSOCT)系统。首先,我们回顾相干复兴的原理,其中当干涉仪的两个臂与激光腔长度的整数倍不匹配时,由外腔可调谐激光器(ECTL)照射的干涉仪会显示干涉条纹。其次,我们报告观察到,当臂长不匹配时,从采用某些ECTL的SSOCT系统获得的光谱干涉图会自动进行相位调制。这种相位调制会产生频移干涉图,从而有效地创建了扩展深度的外差SSOCT系统,而无需使用声光或电光调制器。我们建议,这种相位调制可能是由ECTL腔的光程长度随激光扫描范围的变化而引起的,并通过数值模拟来支持这一假设。我们还报告了成功使用两台商业扫描光源激光器成功实施该技术的情况,该激光器工作于840nm和1040nm,扫描速率分别为8kHz和100kHz。通过测量干涉仪臂匹配和不匹配的每个激光器的灵敏度下降曲线,可以证明该技术提供的扩展成像深度。通过对健康人类志愿者的眼前节进行成像,证明了该技术在临床系统中的可行性。

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