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Characterization of a 3D optrode array for infrared neural stimulation

机译:用于红外神经刺激的3D电极阵列的表征

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摘要

This paper characterizes the Utah Slant Optrode Array (USOA) as a means to deliver infrared light deep into tissue. An undoped crystalline silicon (100) substrate was used to fabricate 10 × 10 arrays of optrodes with rows of varying lengths from 0.5 mm to 1.5 mm on a 400-μm pitch. Light delivery from optical fibers and loss mechanisms through these Si optrodes were characterized, with the primary loss mechanisms being Fresnel reflection, coupling, radiation losses from the tapered shank and total internal reflection in the tips. Transmission at the optrode tips with different optical fiber core diameters and light in-coupling interfaces was investigated. At λ = 1.55μm, the highest optrode transmittance of 34.7%, relative to the optical fiber output power, was obtained with a 50-μm multi-mode fiber butt-coupled to the optrode through an intervening medium of index n = 1.66. Maximum power is directed into the optrodes when using fibers with core diameters of 200 μm or less. In addition, the output power varied with the optrode length/taper such that longer and less tapered optrodes exhibited higher light transmission efficiency. Output beam profiles and potential impacts on physiological tests were also examined. Future work is expected to improve USOA efficiency to greater than 64%.
机译:本文将犹他州倾斜斜光阵(USOA)表征为一种将红外光深入组织内的方法。使用未掺杂的晶体硅(100)衬底来制造10×10的光电二极管阵列,其行距在400-μm范围内从0.5mm到1.5mm不等。通过这些硅电极对光纤的光传输和损耗机理进行了表征,主要损耗机理为菲涅耳反射,耦合,锥柄辐射损耗和尖端的全内反射。研究了在具有不同光纤芯直径和光耦合界面的光极尖端处的传输。在λ=1.55μm处,通过折射率为n = 1.66的中介介质将50μm多模光纤对接耦合到光极,可获得相对于光纤输出功率最高的光极透射率,为34.7%。当使用纤芯直径为200μm或更小的光纤时,将最大功率引入电极。另外,输出功率随光极长度/锥度的变化而变化,使得更长和更少锥度的光极表现出更高的光传输效率。还检查了输出光束轮廓和对生理测试的潜在影响。未来的工作有望将USOA效率提高到64%以上。

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