Regulation of ovulation number in mammals. A follicle interaction law that controls maturation.

摘要

The assumption that developing follicles communicate through circulating hormones has been used to obtain a class of interaction laws that describe follicle growth. A specific member of this class has been shown to control ovulation number. Although all interacting follicles obey the same growth law and are given initial maturities that are chosen at random from a uniform distribution, ovulatory and atretic follicles emerge. Changing the parameters in the growth law can alter the most probable ovulation number values, anovulatory states are also admitted as possible solutions of the growth law. The behavior of the model is examined for interacting follicle populations of different size. Methods are suggested for identifying growth laws in particular mammals. These can be used to test the model from experimental data.