Differential roles of tryptophan residues in conformational stability of Porphyromonas gingivalis HmuY hemophore

摘要

BackgroundWe have previously shown that the P. gingivalis HmuY hemophore-like protein binds heme and scavenges heme from host hemoproteins to further deliver it to the cognate heme receptor HmuR. The aim of this study was to characterize structural features of HmuY variants in the presence and absence of heme with respect to roles of tryptophan residues in conformational stability.