IRSS: a web-based tool for automatic layout and analysis of IRES secondary structure prediction and searching system in silico

摘要

BackgroundInternal ribosomal entry sites (IRESs) provide alternative, cap-independent translation initiation sites in eukaryotic cells. IRES elements are important factors in viral genomes and are also useful tools for bi-cistronic expression vectors. Most existing RNA structure prediction programs are unable to deal with IRES elements.