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Dynamic simulation of regulatory networks using SQUAD

机译:使用SQUAD动态仿真监管网络

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摘要

BackgroundThe ambition of most molecular biologists is the understanding of the intricate network of molecular interactions that control biological systems. As scientists uncover the components and the connectivity of these networks, it becomes possible to study their dynamical behavior as a whole and discover what is the specific role of each of their components. Since the behavior of a network is by no means intuitive, it becomes necessary to use computational models to understand its behavior and to be able to make predictions about it. Unfortunately, most current computational models describe small networks due to the scarcity of kinetic data available. To overcome this problem, we previously published a methodology to convert a signaling network into a dynamical system, even in the total absence of kinetic information. In this paper we present a software implementation of such methodology.
机译:背景技术大多数分子生物学家的抱负是对控制生物系统的复杂分子相互作用网络的理解。随着科学家发现这些网络的组成部分和连通性,有可能从整体上研究其动态行为并发现每个组成部分的具体作用是什么。由于网络的行为绝不是直观的,因此有必要使用计算模型来了解其行为并能够对其做出预测。不幸的是,由于缺乏可用的动力学数据,大多数当前的计算模型都描述了小型网络。为了克服这个问题,我们先前发布了一种方法,即使完全没有动力学信息,也可以将信号网络转换为动力系统。在本文中,我们介绍了这种方法的软件实现。

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