Comparison of transcriptional responses in liver tissue and primary hepatocyte cell cultures after exposure to hexahydro-1 3 5-trinitro-1 3 5-triazine

摘要

BackgroundCell culture systems are useful in studying toxicological effects of chemicals such as Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX), however little is known as to how accurately isolated cells reflect responses of intact organs. In this work, we compare transcriptional responses in livers of Sprague-Dawley rats and primary hepatocyte cells after exposure to RDX to determine how faithfully the in vitro model system reflects in vivo responses.