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Selection of peptides binding to metallic borides by screening M13 phage display libraries

机译:通过筛选M13噬菌体展示文库选择与金属硼化物结合的肽

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摘要

BackgroundMetal borides are a class of inorganic solids that is much less known and investigated than for example metal oxides or intermetallics. At the same time it is a highly versatile and interesting class of compounds in terms of physical and chemical properties, like semiconductivity, ferromagnetism, or catalytic activity. This makes these substances attractive for the generation of new materials. Very little is known about the interaction between organic materials and borides. To generate nanostructured and composite materials which consist of metal borides and organic modifiers it is necessary to develop new synthetic strategies. Phage peptide display libraries are commonly used to select peptides that bind specifically to metals, metal oxides, and semiconductors. Further, these binding peptides can serve as templates to control the nucleation and growth of inorganic nanoparticles. Additionally, the combination of two different binding motifs into a single bifunctional phage could be useful for the generation of new composite materials.
机译:背景技术金属硼化物是一类无机固体,其与例如金属氧化物或金属间化合物相比,其鲜为人知和研究。同时,就物理和化学性质(如半导电性,铁磁性或催化活性)而言,它是一类用途广泛且有趣的化合物。这使得这些物质对新材料的产生具有吸引力。对于有机材料和硼化物之间的相互作用知之甚少。为了产生由金属硼化物和有机改性剂组成的纳米结构和复合材料,有必要开发新的合成策略。噬菌体肽展示库通常用于选择与金属,金属氧化物和半导体特异性结合的肽。此外,这些结合肽可以用作模板以控制无机纳米粒子的成核和生长。另外,将两个不同的结合基序组合成单个双功能噬菌体可用于产生新的复合材料。

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