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Combined mutations of ASXL1 CBL FLT3 IDH1 IDH2 JAK2 KRAS NPM1 NRAS RUNX1 TET2 and WT1 genes in myelodysplastic syndromes and acute myeloid leukemias

机译：骨髓增生异常综合症和急性髓细胞性白血病中ASXL1CBLFLT3IDH1IDH2JAK2KRASNPM1NRASRUNX1TET2和WT1基因的组合突变

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BackgroundGene mutation is an important mechanism of myeloid leukemogenesis. However, the number and combination of gene mutated in myeloid malignancies is still a matter of investigation.

机译：背景基因突变是髓样白血病发生的重要机制。然而，髓系恶性肿瘤中基因突变的数量和组合仍是一个研究的问题。

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期刊名称 BMC Cancer
作者
Julien Rocquain; Nadine Carbuccia; Virginie Trouplin; Stéphane Raynaud; Anne Murati; Meyer Nezri; Zoulika Tadrist; Sylviane Olschwang; Norbert Vey; Daniel Birnbaum; Véronique Gelsi-Boyer; Marie-Joelle Mozziconacci;
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年(卷),期 2010(10),-1
年度 2010
页码 401
总页数 7
原文格式 PDF
正文语种
中图分类肿瘤学;
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专利

1. Combined mutations of ASXL1, CBL, FLT3, IDH1, IDH2, JAK2, KRAS, NPM1, NRAS, RUNX1, TET2 and WT1 genes in myelodysplastic syndromes and acute myeloid leukemias [J] . Julien Rocquain, Nadine Carbuccia, Virginie Trouplin, BMC Cancer . 2010,第1期

机译：骨髓增生异常综合症和急性髓细胞性白血病中ASXL1，CBL，FLT3，IDH1，IDH2，JAK2，KRAS，NPM1，NRAS，RUNX1，TET2和WT1基因的组合突变
2. IDH1 and IDH2 mutations are frequent genetic alterations in acute myeloid leukemia and confer adverse prognosis in cytogenetically normal acute myeloid leukemia with NPM1 mutation without FLT3 internal tandem duplication. [J] . Paschka P, Schlenk RF, Gaidzik VI, Journal of Clinical Oncology . 2010,第22期

机译：IDH1和IDH2突变是急性髓细胞性白血病中的常见基因改变，并且在无FLT3内部串联重复的情况下，具有NPM1突变的细胞遗传学正常急性髓细胞性白血病的不良预后。
3. Impact of the variant allele frequency of ASXL1 ASXL1 , DNMT3A DNMT3A , JAK2 JAK2 , TET2 TET2 , TP53 TP53 , and NPM1 NPM1 on the outcomes of patients with newly diagnosed acute myeloid leukemia [J] . Sasaki Koji, Kanagal‐Shamanna Rashmi, Montalban‐Bravo Guillermo, Cancer: A Journal of the American Cancer Society . 2020,第4期

机译：ASX11AS11，DNMT3A DNMT3A，JAK2 JAK2，TET2 TET2，TP53 TP53和NPM1 NPM1对新诊断的急性髓性白血病患者结果的影响
4. Ras gene mutation in acute myeloid leukemia and Myelodysplastic syndromes: a meta-analysis of its occurrence and prognostic relevance [C] . Cheng Jingru, Wang Peng, Zhang Tai, International Conference on Advanced Materials and Computer Science . 2016

机译：RAS基因突变在急性髓性白血病和髓细胞增强综合征中：荟萃分析其发生和预后相关性
5. Detection of Dual IDH1 and IDH2 Mutations by Targeted Next-Generation Sequencing in Acute Myeloid Leukemia and Myelodysplastic Syndromes [O] . Mia Y. Platt, Amir T. Fathi, Darrell R. Borger, 2015

机译：有针对性的下一代白血病和骨髓增生异常综合征的靶向下一代测序检测双重IDH1和IDH2突变。
6. Combined mutations of ASXL1, CBL, FLT3, IDH1, IDH2, JAK2, KRAS, NPM1, NRAS, RUNX1, TET2 and WT1 genes in myelodysplastic syndromes and acute myeloid leukemias [O] . Vey Norbert, Olschwang Sylviane, Tadrist Zoulika, 2010

机译：骨髓增生异常综合症和急性髓性白血病中 ASXL1，CBL，FLT3，IDH1，IDH2，JAK2，KRAS，NPM1，NRAS，RUNX1，TET2和 WT1 基因的组合突变

Combined mutations of ASXL1 CBL FLT3 IDH1 IDH2 JAK2 KRAS NPM1 NRAS RUNX1 TET2 and WT1 genes in myelodysplastic syndromes and acute myeloid leukemias

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