Genome-wide gene copy number and expression analysis of primary gastric tumors and gastric cancer cell lines

摘要

BackgroundGastric cancer is one of the most common malignancies worldwide and the second most common cause of cancer related death. Gene copy number alterations play an important role in the development of gastric cancer and a change in gene copy number is one of the main mechanisms for a cancer cell to control the expression of potential oncogenes and tumor suppressor genes.