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Multicellular tumor spheroid model to evaluate spatio-temporal dynamics effect of chemotherapeutics: application to the gemcitabine/CHK1 inhibitor combination in pancreatic cancer

机译：多细胞肿瘤球体模型评估化学疗法的时空动力学效应：吉西他滨/ CHK1抑制剂组合在胰腺癌中的应用

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BackgroundThe multicellular tumor spheroid (MCTS) is an in vitro model associating malignant-cell microenvironment and 3D organization as currently observed in avascular tumors.

机译：背景技术多细胞肿瘤球体（MCTS）是一种结合恶性细胞微环境和3D组织的体外模型，目前在无血管肿瘤中观察到。

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期刊名称 BMC Cancer
作者
Isabelle Dufau; Céline Frongia; Flavie Sicard; Laure Dedieu; Pierre Cordelier; Frédéric Ausseil; Bernard Ducommun; Annie Valette;
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作者单位

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年(卷),期 2012(12),-1
年度 2012
页码 15
总页数 11
原文格式 PDF
正文语种
中图分类肿瘤学;
关键词
Tumor spheroid Combination Gemcitabine CHK1 inhibitor Pancreatic cancer;

机译：肿瘤球体;组合;吉西他滨;CHK1抑制剂;胰腺癌;

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专利

1. Multicellular tumor spheroid model to evaluate spatio-temporal dynamics effect of chemotherapeutics: application to the gemcitabine/CHK1 inhibitor combination in pancreatic cancer [J] . Isabelle Dufau, Céline Frongia, Flavie Sicard, BMC Cancer . 2012,第1期

机译：多细胞肿瘤球体模型评估化学疗法的时空动力学效应：吉西他滨/ CHK1抑制剂组合在胰腺癌中的应用
2. Multicellular Tumor Spheroids as an In Vivo-Like Tumor Model for Three-Dimensional Imaging of Chemotherapeutic and Nano Material Cellular Penetration [J] . Hui-li Ma, Qiao Jiang, Siyuan Han, Molecular imaging . 2012,第6期

机译：多细胞肿瘤球体作为体内化学疗法和纳米材料细胞渗透三维成像的体内肿瘤模型。
3. Phase I Study of CHK1 Inhibitor LY2603618 in Combination with Gemcitabine in Patients with Solid Tumors [J] . Calvo Emiliano, Braiteh Fadi, Von Hoff Daniel, Oncology: International Journal of Cancer Research and Treatment . 2016,第5期

机译：CHK1抑制剂LY2603618联合吉西他滨治疗实体瘤患者的I期研究
4. Evaluation of Antitumor Activity of Doxorubicin-Loaded Triblock Micelles in 3-D Multicellular Spheroids and Tumor-bearing Mouse Models for Cancer Chemotherapy [C] . T.H.Kim, C. Mount, T. Goodman, Annual meeting exposition of the Controlled Release Society . 2010

机译：阿霉素三嵌段胶束在3-D多细胞球体和荷瘤小鼠模型中的抗癌活性的癌症化疗的评价。
5. Experimental chemotherapeutic approaches in solid tumor spheroids of gastro-intestinal cell lines using the chemotherapeutic drug gemcitabine-HCl (Gemzar(TM)) and the cyclooxygenase inhibitor rofecoxib (Vioxx(TM)). [D] . Intrieri, Gino. 2003

机译：使用化疗药物吉西他滨-HCl（Gemzar™）和环加氧酶抑制剂罗非考昔（Vioxx™）在胃肠道细胞系的实体肿瘤球体中进行实验性化学疗法。
6. Application of Concave Microwells to Pancreatic Tumor Spheroids Enabling Anticancer Drug Evaluation in a Clinically Relevant Drug Resistance Model [O] . Sang-Eun Yeon, Da Yoon No, Sang-Hoon Lee, -1

机译：凹形微孔在胰腺肿瘤小球中的应用可在临床相关耐药模型中评估抗癌药物
7. Multicellular tumor spheroid model to evaluate spatio-temporal dynamics effect of chemotherapeutics: application to the gemcitabine/CHK1 inhibitor combination in pancreatic cancer [O] . Isabelle Dufau, Céline Frongia, Flavie Sicard, 2012

机译：多细胞肿瘤球体模型评估化学疗法的时空动力学效应：吉西他滨/ CHK1抑制剂组合在胰腺癌中的应用

Multicellular tumor spheroid model to evaluate spatio-temporal dynamics effect of chemotherapeutics: application to the gemcitabine/CHK1 inhibitor combination in pancreatic cancer

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