BackgroundThe maternal contribution of transcripts and proteins supplied to the zygote is crucial for the progression from a gametic to an embryonic control of preimplantation development. Here we compared the transcriptional profiles of two types of mouse MII oocytes, one which is developmentally competent (MIISN oocyte), the other that ceases development at the 2-cell stage (MIINSN oocyte), with the aim of identifying genes and gene expression networks whose misregulated expression would contribute to a reduced developmental competence.
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机译：背景提供给合子的转录本和蛋白质的母体贡献对于从配子发育到胚胎控制植入前发育至关重要。在这里，我们比较了两种类型的小鼠MII卵母细胞的转录谱，一种具有发育能力（MII SN 卵母细胞），另一种在2细胞阶段停止发育（MII NSN <旨在鉴定基因和基因表达网络，其表达失调会导致发育能力降低。
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