The human PINK1 locus is regulated in vivo by a non-coding natural antisense RNA during modulation of mitochondrial function

摘要

BackgroundMutations in the PTEN induced putative kinase 1 (PINK1) are implicated in early-onset Parkinson's disease. PINK1 is expressed abundantly in mitochondria rich tissues, such as skeletal muscle, where it plays a critical role determining mitochondrial structural integrity in Drosophila.