Vitamin D supplementation to prevent depression and poor physical function in older adults: Study protocol of the D-Vitaal study a randomized placebo-controlled clinical trial

摘要

BackgroundDepressive symptoms and decreased physical functioning are interrelated conditions and common in older persons, causing significant individual and societal burden. Evidence suggests that vitamin D supplementation may be beneficial for both mental and physical functioning. However, previous randomized controlled trials have yielded inconsistent results and often had suboptimal designs. This study examines the effect of vitamin D supplementation on both depressive symptoms and physical functioning in a high-risk population of older persons with low vitamin D status.