Pneumococcal carriage and antibiotic susceptibility patterns from two cross-sectional colonization surveys among children aged 5 years prior to the introduction of 10-valent pneumococcal conjugate vaccine — Kenya 2009–2010

摘要

BackgroundPneumococci are spread by persons with nasopharyngeal colonization, a necessary precursor to invasive disease. Pneumococcal conjugate vaccines can prevent colonization with vaccine serotype strains. In 2011, Kenya became one of the first African countries to introduce the 10-valent pneumococcal conjugate vaccine (PCV10) into its national immunization program. Serial cross-sectional colonization surveys were conducted to assess baseline pneumococcal colonization, antibiotic resistance patterns, and factors associated with resistance.