BackgroundCancer is a disease characterized as an uncontrolled growth of abnormal cells that invades neighboring tissues and destroys them. Lung cancer is the primary cause of cancer-related deaths in the world, and it diagnosis is a complex task for specialists and it presents some big challenges as medical image interpretation process, pulmonary nodule detection and classification. In order to aid specialists in the early diagnosis of lung cancer, computer assistance must be integrated in the imaging interpretation and pulmonary nodule classification processes. Methods of Content-Based Image Retrieval (CBIR) have been described as one promising technique to computer-aided diagnosis and is expected to aid radiologists on image interpretation with a second opinion. However, CBIR presents some limitations: image feature extraction process and appropriate similarity measure. The efficiency of CBIR systems depends on calculating image features that may be relevant to the case similarity analysis. When specialists classify a nodule, they are supported by information from exams, images, etc. But each information has more or less weight over decision making about nodule malignancy. Thus, finding a way to measure the weight allows improvement of image retrieval process through the assignment of higher weights to that attributes that best characterize the nodules.
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