RND type efflux pump system MexAB-OprM of pseudomonas aeruginosa selects bacterial languages 3-oxo-acyl-homoserine lactones for cell-to-cell communication

摘要

BackgroundBacteria release a wide variety of small molecules including cell>-to>-cell signaling compounds. Gram-negative bacteria use a variety of self-produced autoinducers such as acylated homoserine lactones (acyl>-HSLs) as signal compounds for quorum sensing (QS) within and between bacterial species. QS plays a significant role in the pathogenesis of infectious diseases and in beneficial symbiosis by responding to acyl>-HSLs in Pseudomonas aeruginosa. It is considered that the selection of bacterial languages is necessary to regulate gene expression and thus it leads to the regulation of virulence and provides a growth advantage in several environments. In this study, we hypothesized that RND-type efflux pump system MexAB>-OprM of P. aeruginosa might function in the selection of acyl>-HSLs, and we provide evidence to support this hypothesis.