Coordinated regulation of Myc trans-activation targets by Polycomb and the Trithorax group protein Ash1

摘要

BackgroundThe Myc oncoprotein is a transcriptional regulator whose function is essential for normal development. Myc is capable of binding to 10% of the mammalian genome, and it is unclear how a developing embryo controls the DNA binding of its abundant Myc proteins in order to avoid Myc's potential for inducing tumorigenesis.