Thrombin induces Egr-1 expression in fibroblasts involving elevation of the intracellular Ca2+ concentration phosphorylation of ERK and activation of ternary complex factor

摘要

BackgroundThe serine protease thrombin catalyzes fibrin clot formation by converting fibrinogen into fibrin. Additionally, thrombin stimulation leads to an activation of stimulus-responsive transcription factors in different cell types, indicating that the gene expression pattern is changed in thrombin-stimulated cells. The objective of this study was to analyze the signaling cascade leading to the expression of the zinc finger transcription factor Egr-1 in thrombin-stimulated lung fibroblasts.