Effect of simvastatin on bone markers in osteopenic women: a placebo-controlled dose-ranging trial ISRCTN85429598

摘要

BackgroundHydroxymethylglutaryl coenzyme A reductase inhibitors increase new bone formation in vitro and in rodents. Results of epidemiologic analyses evaluating the association between use of these cholesterol-lowering drugs, bone mineral density and fracture have been mixed.