Prior ingestion of exogenous ketone monoester attenuates the glycaemic response to an oral glucose tolerance test in healthy young individuals

摘要

Key points class="unordered" style="list-style-type:disc" id="tjp12846-list-0001">The recent development of exogenous ketone supplements allows direct testing of the metabolic effects of elevated blood ketones without the confounding influence of widespread changes experienced with ketogenic diets or prolonged fasting.In the present study, we determined the effect of (R)‐3‐hydroxybutyl (R)‐3‐hydroxybutyrate ketone monoester on the glycaemic response and insulin sensitivity index during a 2 h oral glucose tolerance test (OGTT) in humans.The results obtained show that consuming a ketone monoester supplement 30 min prior to an OGTT reduced the glycaemic response and markers of insulin sensitivity without affecting insulin secretion.The findings of the present study provides evidence that ketone supplements could have therapeutic potential for future application as a glucose‐lowering nutritional supplement.