Moderate and severe hypoxia elicit divergent effects on cardiovascular function and physiological rhythms

摘要

Key points class="unordered" style="list-style-type:disc" id="tjp12945-list-0001">In the present study, we provide evidence for divergent physiological responses to moderate compared to severe hypoxia, addressing an important knowledge gap related to severity, duration and after‐effects of hypoxia encountered in cardiopulmonary situations.The physiological responses to moderate and severe hypoxia were not proportional, linear or concurrent with the time‐of‐day.Hypoxia elicited severity‐dependent physiological responses that either persisted or fluctuated throughout normoxic recovery.The physiological basis for these distinct cardiovascular responses implicates a shift in the sympathovagal set point and probably not molecular changes at the artery resulting from hypoxic stress.