A calcium‐dependent pathway underlies activity‐dependent plasticity of electrical synapses in the thalamic reticular nucleus

摘要

Key points class="unordered" style="list-style-type:disc" id="tjp12345-list-0001">Electrical synapses are modified by various forms of activity, including paired activity in coupled neurons and tetanization of the input to coupled neurons.We show that plasticity of electrical synapses that results from paired spiking activity in coupled neurons depends on calcium influx and calcium‐initiated signalling pathways.Plasticity that results from tetanization of input fibres does not depend on calcium influx or dynamics.These results imply that electrically coupled neurons have distinct sets of mechanisms for adjusting coupling according to the specific type of activity they experience.