Mechanically sensitive Aδ nociceptors that innervate bone marrow respond to changes in intra‐osseous pressure

摘要

Key points class="unordered" style="list-style-type:disc" id="tjp12336-list-0001">Sensory neurons that innervate the bone marrow provide the CNS with information about pain associated with bone disease and pathology, but little is known of their function.Here we use a novel in vivo bone–nerve electrophysiological preparation to study how they respond to noxious mechanical stimulation delivered by increasing intra‐osseous pressure.We provide evidence that sensory neurons that innervate the bone marrow respond to high threshold noxious mechanical stimulation, have response properties consistent with a role in nociception, provide information about different features of an intra‐osseous pressure stimulus and express the Piezo2 mechano‐transducer molecule.Our findings show how some bone marrow nociceptors signal pain in bony diseases and pathologies that involve a mechanical disturbance or increased intra‐osseous pressure, and that the Piezo2 mechano‐transducer may be involved.