Experimental and modelling evidence of shortening heat in cardiac muscle

摘要

Key points class="unordered" style="list-style-type:disc" id="tjp12544-list-0001">Heat associated with muscle shortening has been repeatedly demonstrated in skeletal muscle, but its existence in cardiac muscle remains contentious after five decades of study.By iterating between experiments and computational modelling, we show compelling evidence for the existence of shortening heat in cardiac muscle and reveal, mechanistically, the source of this excess heat.Our results clarify a long‐standing uncertainty in the field of cardiac muscle energetics.We provide a revised partitioning of cardiac muscle energy expenditure to include this newly revealed thermal component.