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Comparison of statistical procedures for estimating polygenic effects using dense genome-wide marker data

机译:使用密集的全基因组标记数据估算多基因效应的统计程序比较

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摘要

In this study we compared different statistical procedures for estimating SNP effects using the simulated data set from the XII QTL-MAS workshop. Five procedures were considered and tested in a reference population, i.e., the first four generations, from which phenotypes and genotypes were available. The procedures can be interpreted as variants of ridge regression, with different ways for defining the shrinkage parameter. Comparisons were made with respect to the correlation between genomic and conventional estimated breeding values. Moderate correlations were obtained from all methods. Two of them were used to predict genomic breeding values in the last three generations. Correlations between these and the true breeding values were also moderate. We concluded that the ridge regression procedures applied in this study did not outperform the simple use of a ratio of variances in a mixed model method, both providing moderate accuracies of predicted genomic breeding values.
机译:在这项研究中,我们比较了使用XII QTL-MAS研讨会的模拟数据集估算SNP效果的不同统计程序。在参考人群中,即前四代中,考虑并测试了五种方法,从中可获得表型和基因型。该过程可以解释为岭回归的变体,具有定义收缩参数的不同方法。就基因组和常规估计育种值之间的相关性进行了比较。从所有方法中获得中等相关性。其中两个被用来预测最近三代的基因组育种值。这些与真实育种值之间的相关性也中等。我们得出的结论是,在这项研究中应用的岭回归程序并没有优于简单使用混合模型方法中的方差比,两者均提供了预测基因组育种值的中等准确性。

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