Dysregulation of leukocyte gene expression in women with medication-refractory depression versus healthy non-depressed controls

摘要

BackgroundDepressive Disorders (DD) are a great financial and social burden. Females display 70% higher rate of depression than males and more than 30% of these patients do not respond to conventional medications. Thus medication-refractory female patients are a large, under-served, group where new biological targets for intervention are greatly needed.