Maternal obesity epigenetically alters visceral fat progenitor cell properties in male offspring mice

摘要

Key points class="unordered" style="list-style-type:disc" id="tjp7244-list-0001">Maternal obesity reduces adipogenic progenitor density in offspring adipose tissue.The ability of adipose tissue expansion in the offspring of obese mothers is limited and is associated with metabolic dysfunction of adipose tissue when challenged with a high‐fat diet.Maternal obesity induces DNA demethylation in the promoter of zinc finger protein 423, which renders progenitor cells with a high adipogenic capacity.Maternal obesity demonstrates long‐term effects on the adipogenic capacity of progenitor cells in offspring adipose tissue, demonstrating a developmental programming effect.