The complementary and divergent roles of uncoupling proteins 1 and 3 in thermoregulation

摘要

Key points class="unordered" style="list-style-type:disc" id="tjp12021-list-0001">Both uncoupling protein 1 (UCP1) and UCP3 are important for mammalian thermoregulation.UCP1 and UCP3 in brown adipose tissue mediate early and late phases of sympathomimetic thermogenesis, respectively.Lipopolysaccharide thermogenesis requires skeletal muscle UCP3 but not UCP1.Acute noradrenaline‐induced hyperthermia requires UCP1 but not UCP3.Loss of both UCP1 and UCP3 accelerate the loss of body temperature compared to UCP1KO alone during acute cold exposure.