Obesity‐induced lymphatic dysfunction is reversible with weight loss

摘要

Key points class="unordered" style="list-style-type:disc" id="tjp7460-list-0001">Obesity induces lymphatic leakiness, decreases initial lymphatic vessel density, impairs collecting vessel pumping and decreases transport of macromolecules.Obesity results in perilymphatic inducible nitric oxide synthase (iNOS) expression and accumulation of T cells and macrophages.Deleterious effects of obesity on the lymphatic system correlate with weight gain.Weight loss restores lymphatic function in obese animals and decreases perilymphatic iNOS and inflammatory cell accumulation.