In the beginning: a personal reminiscence on the origin and legacy of ClC-0 the ‘Torpedo Cl− channel’

摘要

This unapologetically subjective essay recalls the Torpedo Cl^– channel in the years when it had neither a molecular identity nor proper name (ClC-0), and membership in a large superfamily. I discuss the circumstances surrounding its discovery and subsequent research through the 1980s that revealed its unusual molecular architecture and other strange mechanistic characteristics.