Ca2+ current facilitation determines short‐term facilitation at inhibitory synapses between cerebellar Purkinje cells

摘要

Key points class="unordered" style="list-style-type:disc" id="tjp6841-list-0001">Short‐term facilitation takes place at GABAergic synapses between cerebellar Purkinje cells (PCs).By directly patch clamp recording from a PC axon terminal, we studied the mechanism of short‐term facilitation.We show that the Ca²⁺ currents elicited by high‐frequency action potentials were augmented in a [Ca²⁺]i‐dependent manner.The facilitation of synaptic transmission showed 4–5th power dependence on the Ca²⁺ current facilitation, and was abolished when the Ca²⁺ current amplitude was adjusted to be identical.Short‐term facilitation of Ca²⁺ currents predominantly mediates short‐term facilitation at synapses between PCs.