Projection to latent pathways (PLP): a constrained projection to latent variables (PLS) method for elementary flux modes discrimination

摘要

BackgroundElementary flux modes (EFM) are unique and non-decomposable sets of metabolic reactions able to operate coherently in steady-state. A metabolic network has in general a very high number of EFM reflecting the typical functional redundancy of biological systems. However, most of these EFM are either thermodynamically unfeasible or inactive at pre-set environmental conditions.