Elucidating the mechanisms of cooperative calcium-calmodulin interactions: a structural systems biology approach

摘要

BackgroundCalmodulin is an important multifunctional molecule that regulates the activities of a large number of proteins in the cell. Calcium binding induces conformational transitions in calmodulin that make it specifically active to particular target proteins. The precise mechanisms underlying calcium binding to calmodulin are still, however, quite poorly understood.