BackgroundGeneral, breed- and diet-dependent associations between feed efficiency in beef cattle and single nucleotide polymorphisms (SNPs) or haplotypes were identified on a population of 1321 steers using a 50 K SNP panel. Genomic associations with traditional two-step indicators of feed efficiency – residual feed intake (RFI), residual average daily gain (RADG), and residual intake gain (RIG) – were compared to associations with two complementary one-step indicators of feed efficiency: efficiency of intake (EI) and efficiency of gain (EG). Associations uncovered in a training data set were evaluated on independent validation data set. A multi-SNP model was developed to predict feed efficiency. Functional analysis of genes harboring SNPs significantly associated with feed efficiency and network visualization aided in the interpretation of the results.
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机译：背景使用50 K SNP面板在1321头公牛群体中确定了肉牛饲料效率与单核苷酸多态性（SNP）或单倍型之间的一般，品种和饮食相关性。将基因组与饲料效率的传统两步指标（残余饲料摄入量（RFI），残余平均日增重（RADG）和残余摄入量（RIG））进行关联，并与两个补充的饲料效率单步指标进行关联：摄入效率（EI）和获取效率（EG）。在培训数据集中发现的关联在独立的验证数据集上进行评估。建立了一个多SNP模型来预测饲料效率。带有SNP的基因的功能分析与饲料效率和网络可视化显着相关，有助于解释结果。
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