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Comparison of genomic and proteomic data in recurrent airway obstruction affected horses using ingenuity pathway analysis®

机译:使用独创性通路分析®比较复发性气道阻塞的马的基因组和蛋白质组学数据

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摘要

BackgroundRecurrent airway obstruction (RAO) is a severe chronic respiratory disease affecting horses worldwide, though mostly in the Northern hemisphere. Environmental as well as genetic factors strongly influence the course and prognosis of the disease. Research has been focused on characterization of immunologic factors contributing to inflammatory responses, on genetic linkage analysis, and, more recently, on proteomic analysis of airway secretions from affected horses. The goal of this study was to investigate the interactions between eight candidate genes previously identified in a genetic linkage study and proteins expressed in bronchoalveolar lavage fluid (BALF) collected from healthy and RAO-affected horses. The analysis was carried out with Ingenuity Pathway Analysis® bioinformatics software.
机译:背景反复呼吸道阻塞(RAO)是一种严重的慢性呼吸道疾病,影响了世界范围内的马匹,尽管大部分发生在北半球。环境因素和遗传因素都强烈影响该疾病的病程和预后。研究集中在有助于炎症反应的免疫学因素的表征,遗传连锁分析以及最近对受影响马的气道分泌物的蛋白质组学分析上。这项研究的目的是调查先前在遗传连锁研究中鉴定出的八个候选基因与从健康和受RAO影响的马匹中收集的支气管肺泡灌洗液(BALF)中表达的蛋白质之间的相互作用。使用Ingenuity Pathway Analysis ®生物信息学软件进行分析。

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