Physiological and analgesic effects of continuous-rate infusion of morphine butorphanol tramadol or methadone in horses with lipopolysaccharide (LPS)-induced carpal synovitis

摘要

BackgroundContinuous-rate infusion (CRI) of drugs results in more stable plasma drug concentrations than administration of intermittent boluses, thus providing greater stability of physiological parameters. The aim of this study was to evaluate the physiologic and analgesic effects of the administration of morphine, butorphanol, tramadol or methadone by CRI in horses with induced synovitis of the radiocarpal joint.