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Association of genetic polymorphisms of CYP2E1 NAT2 GST and SLCO1B1 with the risk of anti-tuberculosis drug-induced liver injury: a systematic review and meta-analysis

机译：CYP2E1NAT2GST和SLCO1B1基因多态性与抗结核药物性肝损伤风险的相关性：系统评价和荟萃分析

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摘要

ObjectivesThe objective of this study was to investigate the association between genetic polymorphisms of N-acetyltransferase 2 (NAT2), cytochrome P450 2E1 (CYP2E1), glutathione S-transferase (GST) and solute carrier organic anion transporter family member 1B1 (SLCO1B1) and the risk of anti-tuberculosis drug-induced liver injury (ATDILI).

机译：目的本研究的目的是研究N-乙酰基转移酶2（NAT2），细胞色素P450 2E1（CYP2E1），谷胱甘肽S-转移酶（GST）和溶质载体有机阴离子转运蛋白家族成员1B1（SLCO1B1）的遗传多态性之间的关联。抗结核药物性肝损伤（ATDILI）的风险。

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期刊名称 BMJ Open
作者
Seungwon Yang; Se Jung Hwang; Jung Yun Park; Eun Kyoung Chung; Jangik I Lee;
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作者单位

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年(卷),期 2019(9),8
年度 2019
页码 e027940
总页数 14
原文格式 PDF
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关键词
anti-tuberculosis drug-induced liver injury genetic polymorphisms meta-analysis drug-metabolizing enzyme drug transporter tuberculosis;

机译：抗结核药物性肝损伤;遗传多态性;荟萃分析;药物代谢酶;药物转运蛋白;结核病;

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专利

1. Association of NAT2, GST and CYP2E1 polymorphisms and anti-tuberculosis drug-induced hepatotoxicity [J] . SinglaN., GuptaD., BirbianN., Tuberculosis . 2014,第3期

机译：NAT2，GST和CYP2E1多态性与抗结核药物诱导的肝毒性的关系
2. CYP2E1 RsaI/PstI polymorphism and risk of anti-tuberculosis drug-induced liver injury: a meta-analysis [J] . Deng R., Yang T., Wang Y., The international journal of tuberculosis and lung disease: the official journal of the International Union against Tuberculosis and Lung Disease . 2012,第12期

机译：CYP2E1 RsaI / PstI基因多态性与抗结核药物性肝损伤的风险：一项荟萃分析
3. NAT2 polymorphisms and susceptibility to anti-tuberculosis drug-induced liver injury: A meta-analysis [J] . WangP.-Y., XieS.-Y., HaoQ., The international journal of tuberculosis and lung disease: the official journal of the International Union against Tuberculosis and Lung Disease . 2012,第5期

机译：NAT2基因多态性与抗结核药物性肝损伤的易感性：荟萃分析
4. Association of APOE and other genetic polymorphisms with prospective concussion risk in a prospective cohort study of college athletes [C] . Terrell Thomas R., Bostick Roberd, Rogers Gary L., 2014 Biomedical Sciences and Engineering Conference . 2014

机译：在大学运动员前瞻性队列研究中，APOE和其他遗传多态性与前瞻性脑震荡风险的关联
5. Genotype misclassification in genetic association studies of the rs1042522 TP53 (Arg72Pro) polymorphism: a systematic review of studies in breast, lung, colorectal, ovarian, and endometrial cancer [D] . Dahabreh, Issa J. 2011

机译：rs1042522 TP53（Arg72Pro）多态性的遗传关联研究中的基因型错误分类：对乳腺癌，肺癌，结直肠癌，卵巢癌和子宫内膜癌研究的系统评价
6. Pharmacogenetic Study of Drug-Metabolising Enzyme Polymorphisms on the Risk of Anti-Tuberculosis Drug-Induced Liver Injury: A Meta-Analysis [O] . Yu Cai, JiaYong Yi, ChaoHui Zhou, -1

机译：有关抗结核病药物性肝损伤的风险药物代谢酶基因多态性的遗传药理学研究的meta分析
7. Pharmacogenetic study of drug-metabolising enzyme polymorphisms on the risk of anti-tuberculosis drug-induced liver injury: a meta-analysis. [O] . Yu Cai, JiaYong Yi, ChaoHui Zhou, 2012

机译：药物代谢酶基因多态性对抗结核药物性肝损伤风险的药物遗传学研究：荟萃分析。

Association of genetic polymorphisms of CYP2E1 NAT2 GST and SLCO1B1 with the risk of anti-tuberculosis drug-induced liver injury: a systematic review and meta-analysis

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