Do non-inferiority trials of reduced intensity therapies show reduced effects? A descriptive analysis

摘要

ObjectivesTo identify non-inferiority trials within a cohort where the experimental therapy is the same as the active control comparator but at a reduced intensity and determine if these non-inferiority trials of reduced intensity therapies have less favourable results than other non-inferiority trials in the cohort. Such a finding would provide suggestive evidence of biocreep in these trials.