Upper limb international spasticity study: rationale and protocol for a large international multicentre prospective cohort study investigating management and goal attainment following treatment with botulinum toxin A in real-life clinical practice

摘要

ObjectivesThis article provides an overview of the Upper Limb International Spasticity (ULIS) programme, which aims to develop a common core dataset for evaluation of real-life practice and outcomes in the treatment of upper-limb spasticity with botulinum toxin A (BoNT-A). Here we present the study protocol for ULIS-II, a large, international cohort study, to describe the rationale and steps to ensure the validity of goal attainment scaling (GAS) as the primary outcome measure.