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Linearity and time-scale invariance of the creep function in living cells.

机译:活细胞中蠕变函数的线性和时标不变性。

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摘要

We report here the creep function measured in three cell types, after a variety of interventions, and over three time decades (from 3 ms to 3.2 s). In each case the response conformed to a power law, implying that no distinct molecular relaxation times or time constants could characterize the response. These results add to a growing body of evidence that stands in contrast to widely used viscoelastic models featuring at most a few time constants. We show instead that the ability of the matrix to deform is time-scale invariant and characterized by only one parameter: the power law exponent that controls the transition between solid-like and liquid-like behaviour. Moreover, we validate linearity by comparison of measurements in the time and frequency domains.
机译:我们在这里报告了经过三种干预后,经过三个时间十年(从3 ms到3.2 s),在三种细胞类型中测得的蠕变函数。在每种情况下,响应均符合幂律,这意味着没有明显的分子弛豫时间或时间常数可以表征响应。这些结果增加了越来越多的证据,这与最多使用几个时间常数的广泛使用的粘弹性模型形成了鲜明对比。相反,我们证明了矩阵变形的能力是时标不变的,并且仅由一个参数来表征:幂律指数控制着固体行为和液体行为之间的过渡。此外,我们通过比较时域和频域中的测量值来验证线性度。

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