Statins 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors potentiate the anti-angiogenic effects of bevacizumab by suppressing angiopoietin2 BiP and Hsp90α in human colorectal cancer

摘要

Background: Statins, 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, are commonly prescribed because of their therapeutic and preventive effects on cardiovascular diseases. Even though they have been occasionally reported to have antitumour activity, it is unknown whether statins have anti-angiogenic effect in human colorectal cancer (CRC).