Role of endoplasmic reticulum stress induction by the plant toxin persin in overcoming resistance to the apoptotic effects of tamoxifen in human breast cancer cells

摘要

Background: Persin is a plant toxin that displays synergistic cytotoxicity with tamoxifen in human breast cancer cell lines. Here, we examined the ability of persin to circumvent tamoxifen resistance and delineated the intracellular signalling pathways involved.