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Dealing with low-incidence serious diseases in general practice

机译:在一般实践中应对低发病率严重疾病

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摘要

Cost-effective health care depends on high-quality triage. The most challenging aspect of triage, which GPs confront on a regular basis, is diagnosing rare but serious disease. Failure to shoulder any risk in this situation overloads the health system and subjects patients to unnecessary investigation. Adopting too high a risk threshold leads to missed cases, late diagnosis, and sometimes avoidable death. It also undermines the credibility of primary care practitioners. Quantification of diagnostic risk suggests there is a potential risk gap between the maximum certainty with which GPs can assess the risk of serious disease at presentation and the minimum certainty required by many health systems for further investigation or hospital referral. Physician gut-feeling and diagnostic safety netting are often employed to fill the gap. Neither strategy is well defined or well supported by evidence. It should be possible to reduce the diagnostic risk gap cost-effectively by adopting more explicit diagnostic algorithms and providing better GP access to new diagnostic technologies. It is also essential, given the decreasing experience of triage clinicians employed in a number of countries, that a teachable evidence base is constructed for gut feeling and diagnostic safety netting. However, this construction of an evidence base requires very large-scale studies, and the global primary care research community remains small. The challenge therefore needs to be met by urgent and effective international collaboration.
机译:具有成本效益的医疗保健取决于高质量的分类。全科医生定期面对的分诊中最具挑战性的方面是诊断罕见但严重的疾病。在这种情况下无法承担任何风险会使卫生系统超负荷,并使患者接受不必要的检查。风险阈值过高会导致漏诊,误诊和有时可避免的死亡。它还破坏了初级保健从业者的信誉。诊断风险的量化表明,全科医生可以在就诊时评估严重疾病的最大确定性与许多医疗系统进行进一步调查或转诊所需的最小确定性之间存在潜在的风险差距。经常采用医师内脏感觉和诊断安全网来填补空白。既没有明确定义策略也没有证据支持。通过采用更明确的诊断算法并为新的诊断技术提供更好的GP接入,应该可能有成本效益地减少诊断风险差距。鉴于在许多国家/地区使用的分诊临床医生的经验越来越少,同样重要的是,要为肠道感觉和诊断安全网建立可教学的证据基础。但是,这种证据基础的构建需要非常大规模的研究,全球初级保健研究界仍然很小。因此,需要通过紧急和有效的国际合作来应对这一挑战。

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