AIMS--The study was set up to evaluate the effect of microwave cyclodestruction on human eyes. METHODS--Two human eyes were studied. For treatment a horn shaped 5.8 GHz microwave applicator and fibre optic thermometry were used. Just before enucleation, the rectangular (2 x 3 mm) microwave aperture was placed onto the conjunctiva at a position 1-2 mm posterior to the corneal scleral limbus. Each of three to four treatment spots was targeted to receive a thermal dose of 54 degrees C for 1 minute. Clinical, gross, and histopathological evaluations were performed. RESULTS--Clinical evaluations of the treatment sites (immediately after microwave application) revealed no evidence of conjunctival or scleral damage. Trace fluorescein 2% uptake was noted within the targeted zones. The first eye was sectioned along the equatorial axis. Examination of the ciliary body and pars plana revealed whitening of the ciliary processes and depigmentation. Histopathological evaluations revealed ciliary epithelial necrosis with pigment dispersion. The vascularity of the ciliary processes showed focal disruption and haemorrhage. The underlying ciliary muscle and sclera appeared to be unaffected. No other findings could be attributed to microwave cyclodestruction. CONCLUSION--The results of this phase I toxicity study suggest that microwave heating can be used to damage preferentially the epithelial layers of the human ciliary body.
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机译:目的-这项研究旨在评估微波环毁对人眼的影响。方法-研究了两只人的眼睛。为了进行处理,使用了喇叭形的5.8 GHz微波辐射器和光纤测温仪。即将摘除前,将矩形(2 x 3毫米)微波孔径放在结膜上角膜巩膜角膜缘后1-2毫米的位置。将三到四个治疗点中的每一个定位为接受54摄氏度的热剂量1分钟。进行了临床,总体和组织病理学评估。结果-对治疗部位的临床评估(在微波应用后立即进行)显示没有结膜或巩膜损伤的证据。在目标区域内发现了2%的微量荧光素吸收。第一只眼睛沿赤道轴剖开。睫状体和睫状体的检查显示睫状突变白和色素沉着。组织病理学评估显示睫状上皮坏死伴有色素分散。睫状突的血管显示局灶性破坏和出血。潜在的睫状肌和巩膜似乎未受影响。没有其他发现可归因于微波环毁。结论-第一阶段毒性研究的结果表明,微波加热可优先用于破坏人睫状体的上皮层。
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