RU486 is both a progesterone blocker and a corticosteroid blocker (peripheral). Subconjunctival injections of 0.2 ml of a 1% suspension of RU486 powder (2 mg) were given twice weekly to one eye chosen at random of 12 rabbits. The fellow eye received the same volume, 0.2 ml, of vehicle (normal saline) only. Ocular tension was measured twice daily for six days per week by an Alcon pneumatonograph, the tonometrist(s) being unaware of which eyes were treated and which untreated. A small but significant reduction in intraocular pressure, about 0.7 mmHg, occurred in treated eyes. No intereye difference in the ocular hypertensive response to intraperitoneal injections of distilled water (50 ml/kg) was found. Clinical trials are planned in which a larger fall is expected because the trabecular meshwork in patients with open-angle glaucoma or ocular hypertension is presumably more affected by (normal) tissue levels of corticosteroid.
展开▼
机译：RU486既是孕激素受体阻滞剂，也是皮质类固醇激素阻滞剂（外围）。每周两次向结膜下注射0.2 ml 1％RU486粉末（2 mg）的混悬液，随机选择12只兔子的一只眼睛。另一只眼睛只接受了相同体积的0.2毫升媒介物（生理盐水）。每周两次，每天六次，用Alcon肺动脉造影仪测量眼压，该眼压仪不知道哪些眼睛被治疗和哪个眼睛未被治疗。经治疗的眼睛的眼压略有降低，但显着降低，约为0.7 mmHg。未发现对腹膜内注射蒸馏水（50 ml / kg）的眼高压反应的眼间差异。计划进行临床试验的患者预计跌幅更大，因为开角型青光眼或高眼压患者的小梁网可能受皮质类固醇（正常）组织水平的影响更大。
展开▼
